MegaSporeBiotic is not your typical probiotic that attempts to “reseed” or recolonize the gut. Reseeding probiotics (such as Lactobacillus or Bifidobacteria species) are often poor choices due to low potency, fragility, susceptibility to antibiotics, and low survivability in the capsule and through the harsh gastric system. If they do make it to the GI tract, many will not “find a home” in the gut and thus will not provide a health benefit.
On the other hand, spore-forming Bacillus probiotics are true probiotics which “recondition” the gut. They won’t lose potency during manufacture, shipping and storage and they survive harsh stomach conditions, plus they are normal residents in the human gut. As a true probiotic, they work by making conditions better for your resident healthy gut microbes to grow and flourish. They promote a diversity of microbes, a key indicator of a healthy gut. Restoring the balance of healthy gut microbes also crowds out disease-causing pathogens like C. difficile.
MegaSporeBiotic probiotic is now one of the top selling professional supplements on the market today! It’s recommended by over 30,000 health care practitioners (beware of Amazon). MegaSpore has 14 peer-reviewed clinical studies performed so far, and counting.
Learn More About MegaSporeBiotic
Safety of MegaSporeBiotic
There are many studies that show the safety and efficacy of MegaSporeBiotic and its Bacillus spore ingredients. And Microbiome Labs, the makers of MegaSporeBiotic, is dedicated to ongoing research.
Find answers to commonly asked questions about MegaSporeBiotic, including safety, effectiveness, shelf life, side effects, stability during shipping and storage, and usage questions.
MegaSporeBiotic is the first 100% spore, physician’s-strength probiotic with scientifically proven 100% survivability through the stomach and into the gut1. It’s been shown to maintain a healthy gut microbiome, healthy gut barrier function and MegaSporeBiotic is the subject of multiple clinical studies proving it’s diverse health benefits, safety and effectiveness.
MegaSporeBiotic is ideal for gut overgrowth infections as well as long-term, ongoing probiotic support. It is an excellent addition to the CD Herbal Detox Protocol for broad-spectrum immune support and prevention and is part of the probiotic therapy in the Probiotic Restoration Guide.
This potent probiotic contains a blend of five species of Bacillus spore probiotics and delivers 4 billion cells daily to your intestines, the highest level on the market for a spore probiotic. Each batch of product is laboratory tested to verify the correct species, that all species are in 100% spore form and that the proper potency of each species is present. The five strains found in the product are detailed below:
Bacillus subtilis, HU58
The HU58 strain produces over a dozen natural antibiotic substances inside the gut. This powerful strain also produces vitamin K2 and other nutrients and plays a key role in immune system development.
Bacillus coagulans (SC-208)
Many studies and a long history of use show the benefits of B. coagulans for support with ulcerative colitis, Crohn’s disease and IBS. This species is a potent stimulator of the immune system and also produces nutrients in the gut.
Bacillus clausii (SC-109)
The most commonly used probiotic drug species worldwide, B. clausii resists being killed by antibiotics during antibiotic treatment. It also has immune stimulating properties.
Bacillus licheniformis (SL-307)
This Bacillus strain produces bacitracin, a natural antibiotic. It aids the body to digest proteins through protease production and produces a broad spectrum of B vitamins and folic acid.
Bacillus indicus, HU36
This proprietary strain of B. indicus stimulates the immune system and produces carotenoid antioxidants inside your gut, including beta-carotene, lutein, lycopene and the powerful antioxidant astaxanthin. It also produces vitamins and other nutrients in the gut. The unique properties of the HU36 strain make MegaSporeBiotic the first commercially available probiotic-antioxidant combination supplement on the market, supplying antioxidants directly to the GI tract where they are best absorbed.
Natural antibiotic substances1
Bacillus subtilis HU58
Producing more than 12 effective, natural antibiotic substances, HU58 is highly important for immune development, as the gut contains 70% of your immune system.
Immune-supporting antioxidants2
Bacillus indicus HU36
Provides potent immune support, producing carotenoids, astaxanthin, beta carotene, lycopene, lutein, quinols and various vitamins, all of which can help maintain healthy antioxidant levels.
%
Reduction in leaky gut3
Bacillus clausii SC-109
The most commonly used probiotic drug species worldwide, B. clausii provides potent immune support and it resists being killed by antibiotic drugs during antibiotic treatment.
%
Reduction in visceral fat4
Bacillus coagulans SC-208
Has been extensively studied with a long history of safe and effective use. Many studies have tested its efficacy on supporting the gut microbiome, showing it can produce lactic acid and support immune function.
Classes of natural antibiotics5
Bacillus licheniformis SL-307
Can produce natural antibiotic substances and improve protein digestion via production of protease enzymes. These spores even have a capacity to produce a broad spectrum of highly bioavailable B-vitamins, including folic acid (B9).
Bacillus References:1 Stein T. Bacillus subtilis antibiotics: structures, syntheses and specific functions. Molecular Microbiology. 2005;56(4):845-857. 2 Khaneja R, et al. Carotenoids found in Bacillus. J of App Microbiol. 2010;108:1889-1902. 3 Dang, H.T., Tran, D.M., Phung, T.T.B. et al. Promising clinical and immunological efficacy of Bacillus clausii spore probiotics for supportive treatment of persistent diarrhea in children. Sci Rep 14, 6422 (2024). https://doi.org/10.1038/s41598-024-56627-9. 4 McFarlin, B.K., Tanner, E.A., Hill, D.W. et al. Prebiotic/probiotic supplementation resulted in reduced visceral fat and mRNA expression associated with adipose tissue inflammation, systemic inflammation, and chronic disease risk. Genes Nutr 17, 15 (2022). https://doi.org/10.1186/s12263-022-00718-7. 5 Shleeva MO, Kondratieva DA, Kaprelyants AS. Bacillus licheniformis: A Producer of Antimicrobial Substances, including Antimycobacterials, Which Are Feasible for Medical Applications. Pharmaceutics. 2023; 15(7):1893. https://doi.org/10.3390/pharmaceutics15071893
Bacillus Probiotics Can Do What?
These Bacillus probiotics work differently than common reseeding probiotics. They work to create an environment inside your gut that gives a tremendous growth boost to beneficial gut bacteria like Lactobacillus, Bifidobacteria and Akkermansia. These 5 Bacillus strains possess unique and astounding health qualities, as detailed below:
Improve and repair leaky gut2 and significantly reduce endotoxemia in just 30 days
Produce natural antibiotics to help control intestinal bacterial overgrowth
Reduce triglyceride levels (cholesterol)
Protect the liver (equal to milk thistle)
Reduce symptoms of IBS, ulcerative colitis and C. diff. infections
Enhance the immune system and reduce side effects of antibiotic drugs
Recondition and improve gut microbiome diversity and increase beneficial keystone strains including Akkermansia
Aids in digestion and improve regularity
Reduce intestinal and systemic inflammation induced from leaky gut2
Detoxify the intestinal tract
Heal damaged intestines by reducing intestinal inflammation and colitis
Produce more lactic acid than conventional probiotics, for enhanced immune system mobilization
Produce key nutrients: antioxidants (via HU36™), B-vitamins, Vitamin K2, Nattokinase, and CoQ10
Provide immune modulation for the prevention and treatment of infections, allergies and asthma
How MegaSporeBiotic Fights Disease-Causing Bacteria
Below is a video with Kiran Krishnan, Microbiologist and Chief Scientific Officer of Microbiome Labs, sharing how the MegaSporeBiotic probiotic fights bad bacteria and promotes the growth of your friendly gut bacteria. Click the play button below to watch. If you cannot see the video player below, then click the link below, or the blue button to watch on YouTube:
In addition to the above benefits, some Bacillus probiotics target disease causing bacteria, including C. difficile. C. difficile produces a toxin in the intestines that causes diarrhea and inflammation of the colon.
For decades, Bacillus probiotics have been used widely around the world for fighting off intestinal pathogens, antibiotic associated diarrhea and improving immune system function. Below are some of the benefits of Bacillus probiotics for C. difficile:
B. coagulans therapy has shown to improve C. difficile colitis symptoms, reduce colon inflammation, provide better stool consistency and improve C. diff. outcomes3 as well as reduce recurring C. diff. after vancomycin treatment4.
Bacillus clausii makes the antimicrobial compound clausin that directly inhibits C. difficile and other Gram-positive bacteria5.
Bacillus clausii creates an enzyme that helps break apart C. difficile toxins, resulting in a strong protective effect against intestinal damage6.
Bacillus subtilis HU58 produces over 12 targeted antimicrobial substances. B. subtilis effectively targets harmful gut bacteria, making it a potent and effective tool to rebalance gut flora.
Bacillus subtilis enhances the immune system in elderly subjects as indicated by increased immunoglobulin A (IgA) levels7. IgA fights off invading organisms and is your body’s first line of defense.
Recurrent C. difficile Study Results
A 2020 study8 published in the Journal of Parenteral and Enteral Nutrition demonstrated that mice with recurring C. difficile infections had improved markers of gut integrity, inflammation and immunity when supplemented with targeted spore-forming Bacillus probiotics (the five bacillus strains in MegaSporeBiotic). Mice in the control group where no Bacillus strains were given did not receive the same improvement of gut health and immunity.
This study also found that mice supplemented with the Bacillus probiotics had less loss of colon bacteria from the antibiotic treatment than the control group where no Bacillus was supplemented. These five Bacillus probiotic strains found in MegaSporeBiotic were shown to help protect intestinal health during a C. difficile infection.
Study conclusion: Mice supplemented with targeted spore-forming probiotics exhibited improved immune responses and nutrition immunity properties, which were linked with less inflammation and enhanced intestinal barrier proteins during recurrent C. difficile colonization.
Proven Safety
Is MegaSporeBiotic safe? In short, YES! MegaSporeBiotic was carefully formulated by a collaboration of microbiologists, doctors, and researchers, with careful attention paid to the safety and scientific rationale of the strains or species used. The majority of probiotic manufacturers never conduct any safety or efficacy studies on their probiotics. In contrast, Microbiome Labs, the maker of MegaSporeBiotic, has completed 14 studies showing the safety and efficacy for numerous health conditions. Their dedication to continued research is a huge reason I love this probiotic, and it’s also why over 30,000 health practitioners around the world trust MegaSporeBiotic.
Unfortunately, there are a few websites that make unfounded claims about MegaSporeBiotic’s lack of safety. It’s important that you have confidence in the safety of any supplement that you take, so our MegaSporeBiotic safety page will set the record straight. After reading the safety page, you will have all the assurance you need that MegaSporeBiotic is more than just safe – it also has a proven track record of real-world clinical effectiveness. Learn more about why MegaSporeBiotic is safe and effective by clicking the link below:
Hippocrates, the father of modern medicine, said that “all disease begins in the gut”. The GI system is meant to be a protective barrier between what’s in your gut and your bloodstream. Food you ingest and the microorganisms that live in the GI system should stay inside this protective barrier. However, the very common issue of leaky gut allows harmful substances like food particles and gut bacterial toxins to enter your bloodstream. Over time this can result in chronic inflammation and chronic disease.
Today more than ever, people struggle with all kinds of autoimmune disorders and other inflammatory diseases that decrease quality of life and make infection recovery more difficult. Conditions like leaky gut, IBS, IBD, Crohn’s and SIBO all have a strong link to the health of the gut microbiome. And these disorders often set the stage for a host of other chronic disease conditions.
In fact, leaky gut syndrome (or metabolic endotoxemia) is becoming recognized as a primary driver of the following diseases:
Inflammatory bowel disease (IBD)
Autoimmunity
Obesity
Type 2 diabetes
Heart disease
Cognitive decline
Immune dysfunctions and even conditions like Parkinson’s disease.
Impressive Study Results on Leaky Gut
A study from August 2017 looked at MegaSporeBiotic and “leaky gut” and was published in the World Journal of Gastrointestinal Pathophysiology2. Below are the key finding from this study:
Just 30 days of taking MegaSporeBiotic significantly reduced the endotoxic “leaky gut” response.
Just 30 days of taking MegaSporeBiotic effectively fixed their gut lining, favorably altered the immunological response to food, significantly decreased both digestive and systemic inflammation, and in doing so, reduced a major hallmark of chronic degenerative disease.
MegaSporeBiotic was able to restore some communication between the gut and the brain.
With 30 days of MegaSporeBiotic, the microbiome was changed from a non-protective confirmation to a protective confirmation, blocking the influx of highly toxic LPS (bacterial endotoxins) into the bloodstream after a meal.
30 days of MegaSporeBiotic therapy also saw trends towards better insulin responses to the challenge meal, indicating that MegaSporeBiotic likely conducts a favorable modulation of the endocrine response to food.
Systemic, chronic immune activation from leaky gut is believed to be the driving force behind autoimmunity and IBD. Those using MegaSporeBiotic saw a significant reduction in chronic immune activation.
This is the first time that a probiotic has been shown to significantly reduce intestinal inflammation and activate the immune system to improve leaky gut symptoms in human subjects.
Given the study result above, consider the benefits of Bacillus probiotics with the following symptoms, or if you’ve used antibiotic drugs recently:
Autoimmune Disorders
Leaky Gut Syndrome, Seasonal Allergies, Food Allergies and Food Sensitivities
Candida, Clostridium difficile, Helicobacter pylori, Parasites and Gut Overgrowths
Small Intestinal Bacterial Overgrowth (SIBO), Small Intestinal Fungal Overgrowth (SIFO)
Metabolic Syndrome
Skin Conditions: Psoriasis, Eczema, Acne
We’re Here to Support You
Michelle strives to provide you with the best value and personal assistance on the most effective products. Michelle and her staff are here to answer your questions, walk you through her protocols and methods and to provide ongoing support on your path to health.
If you’re a reader of one of Michelle’s books, special pricing is available to you on some of our products. Please visit your online customer area for access to these special discounts. Some discounts are also offered through Michelle’s various free reports and e-courses, so be sure to refer to those for your specially priced product links. You also get FREE SHIPPING on U.S. orders over $99.
Visit our customer reviews and testimonials page few words from our customers from over the years. We’re blessed and thankful to have helped so many people on their personal path to healing.
If you only choose one product, then MegaSporeBiotic is a great choice. It’s ideal for gut infection support and microbiome reconditioning. It’s also great for long-term daily use and immune support.
MegaSporeBiotic plus Mega IgG2000 for added G.I. toxin binding and inflammation support, plus RestorFlora for diarrhea support. This is our most popular pack and is ideal for use during active gut infections.
Microbiome Labs, the maker of MegaSporeBiotic, does not sell their products on Amazon, nor do they authorize any sellers on Amazon.com except the Fortress store.
Many unsuspecting Amazon customers believe they are ordering directly from Microbiome Labs, but they are purchasing from fraudulent sellers. According to reviews, many have received ineffective or fake products. Microbiome Labs tested some of these fake Amazon products and verified that the products had been tainted and tampered with. Some of these fake Amazon stores look quite legitimate and professional, but they are not.
Microbiome Labs products may only be sold through authorized professionals on their own websites. We’ve been an authorized seller since 2017. Rest assured, you will receive genuine products through our store.
We have the lowest prices on the Microbiome Labs probiotics on the internet, and frequently have discounted sales. Plus you get personalized support and care on using our professional grade products and you support our family-owned business that’s been helping people overcome chronic infections since 2007.
References
Commissioned gastric model study by Silliker Food Science Center – Crete, IL
Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers, Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, Kimberly M Carbajal; World J Gastrointest Pathophysiol 2017 August 15; 8(3): 117-126
Bacillus Coagulans GBI-30 (BC30) improves indices of Clostridium difficile-Induced colitis in mice. Fitzpatrick L, Small J, Greene W, Karpa K, Keller D. Gut Pathog. 2011; 3: 16.
Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice. Fitzpatrick L, Small J, Greene W, Karpa K, Farmer S, Keller D. Gut Pathog. 2012; 4: 13.
Probiotics for Prevention of Clostridium difficile Infection. Mills J, Rao K, Young V. Curr Opin Gastroenterol. 2018 Jan; 34(1): 3–10.
Secreted Compounds of the Probiotic Bacillus clausii Strain O/C Inhibit the Cytotoxic Effects Induced by Clostridium difficile and Bacillus cereus Toxins. Ripert G. et al. Antimicrob Agents Chemother. 2016 Jun; 60(6): 3445–3454.
Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study. Lefevre M, Racedo SM, Ripert G, et al. Immun Aging. 2015;12:24
A Spore-Forming Probiotic Supplement Improves the Intestinal Immune Response and Protects the Intestinal Health During Recurrent Clostridioides difficile Colonization in Mice. Fatemeh Ramezani Kapourchali, Bryan Glueck, Yingchun Han. JPEN J Parenter Enteral Nutr. 2020 Nov;44(8):1428-1438. https://pubmed.ncbi.nlm.nih.gov/32495964/
Shopping Cart
We Value Your Privacy
We use cookies to enhance your browsing experience, serve personalized content, and analyze our traffic. By clicking “Accept” or using our site, you consent to our use of cookies.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
